Monster Hunter Rise is an action role-playing video game developed and published by Capcom for the Nintendo Switch. The sixth mainline installment in the Monster Hunter series, it was released worldwide in March 2021, with a Microsoft Windows port released in January 2022. An expansion pack, Monster Hunter Rise: Sunbreak, was released in June 2022. Ports for PlayStation 4, PlayStation 5, Xbox One, and Xbox Series X/S were released on January 20, 2023, with the Sunbreak expansion to follow later in that year.

Rise follows many of the new conventions established in Monster Hunter: World while also introducing new features and mechanics, including a new animal companion called a Palamute that can be used to ride across the map or into battle, and the use of Wirebugs to traverse the world and mount and ride certain monsters. The game received generally positive reviews upon release with critics praising the gameplay and its expansion of the mechanics introduced in World. It has sold more than 11 million copies worldwide since launch, making it the second best-selling game in the series.

After the end of the Rampage, the hunter is hailed as a hero and peace returns to Kamura. This peace turns out to be short-lived, as a hermit crab-like monster, a Daimyo Hermitaur arrives in the shrine ruins. The Hunter and Utsushi investigate and slay the Hermitaur but a new, strange werewolf-like monster suddenly appears out of nowhere and attacks the two. They are unable to defeat it until the arrival of a knight from Elgado named Fiorayne, who repels the monster, then explains that the monster is a Lunagaron from the kingdom of Elgado.

Fiorayne shares that her purpose in Kamura is to recruit the Hunter to help the people of Elgado face a trio of monsters called the Three Lords. One of the Three Lords, a vampyric elder dragon known as Malzeno, is believed to be making the monsters more aggressive and driving them out of the kingdom. As the monsters from Elgado are now threatening Kamura as well, Fugen accepts Fiorayne's request and allows the Hunter to travel to Elgado in order to meet its commander and defeat Malzeno.

Arriving in Elgado, the Hunter meets Admiral Galleus and his allies. The Hunter and Fiorayne soon face the first of the Three Lords, Garangolm, and defeat it. The Hunter and Elgado's lead scientist, Bahari, encounter a species of glowing red moth-like creatures called Qurio. Bahari believes the Qurio may somehow be responsible for the madness plaguing the monsters of Elgado. The Hunter and Fiorayne soon face Lunagaron again, who is the second of the Three Lords, and defeat it as well, but are ambushed by Malzeno, who seems to be commanding the Qurio. Malzeno poisons Fiorayne with a virus from the Qurio as it departs.

With Fiorayne's life in danger, the Hunter seeks out a doctor named Tadori, who is able to create a cure for the virus. Now convinced Malzeno is the source of the Qurio, Galleus commands the Hunter and Fiorayne to defeat the dragon once and for all. The Hunter and Fiorayne confront Malzeno in Elgado's destroyed citadel and slay it, causing a swarm of Qurio to fly away from its corpse. The threat seemingly ended, the people of Elgado begin to relax, but Galleus is concerned something else is at work and begins construction of a fleet of ships armed with dragonators.