Calvin Klein Inc. is an internationally operating, American fashion house. The company, which became famous for its designer underwear and denim lines in the 1980s, specializes in mass-market ready-to-wear clothing for all genders and age groups as well as leather products, lifestyle accessories and shoes, home furnishings, perfume/cosmetics, eyewear, jewellery and watches in the mid-price segment. Its high-end runway fashion division, which represented the top level of the various Calvin Klein sub-brands, was discontinued in 2019.

The company was founded by designer Calvin Klein and his childhood friend, Barry K. Schwartz, in 1968 and was acquired by PVH Corp. for a total of $700 million in 2003. It is headquartered in Midtown Manhattan, New York City, and has substantial market share in retail and commercial lines around the globe. In 2013, PVH bought Warnaco Group, one of the largest Calvin Klein licensees, for around $3 billion. Global retail sales under the Calvin Klein brand, including sales by the label's 40 licensees, amounted to $8.5 billion in 2021.