Whitney: The Greatest Hits is a compilation album by American singer Whitney Houston, released in May 2000. The set consists of disc one with ballads and disc two with uptempo numbers and remixes, spanning the first 15 years of Houston's music career. Houston's performance of "The Star-Spangled Banner" at Super Bowl XXV, and 1988 Olympics tribute "One Moment in Time" are also included in the set. The collection includes four new songs—"Could I Have This Kiss Forever", duet with Enrique Iglesias, "If I Told You That", duet with George Michael, "Same Script, Different Cast", duet with Deborah Cox and "Fine"—all of which were released as singles. It also includes three other songs that had never appeared on a Houston album: "One Moment in Time", "The Star Spangled Banner", and "If You Say My Eyes Are Beautiful", a duet with Jermaine Jackson from his 1986 Precious Moments album. Along with the album, an accompanying VHS and DVD was released featuring the music videos to Houston's greatest hits, as well as several hard-to-find live performances including her 1983 debut on The Merv Griffin Show, and interviews.

Houston's compilation album had been in development for several years prior to its release. As early as 1995, Billboard listed Houston's Greatest Hits album as an upcoming release scheduled for October of that year. Billboard magazine mentioned a "long-promised" Greatest Hits collection again in July 1996, this time due that autumn. Speculation on the timing of the release continued into 1997, with Houston quoted that year as saying: "Oh, Clive is on my case about this greatest hits album. He's like, Whitney, we have to do a greatest hits album, I mean you're far long overdue."

Upon its release, Whitney: The Greatest Hits was a great commercial success and received generally good reviews, although some critics questioned the inclusion of some remixes on Disc Two instead of the original song versions. The album peaked within the top ten in most countries of the Americas, Europe, Asia, Africa, as well as Australia and New Zealand. It received numerous multi-platinum and platinum awards.

After Houston's passing in February 2012, it saw a resurgence in sales and re-entered album charts in many countries around the world. In the United States, it reached a new peak of number two on the US Billboard 200 chart. In July 2012, it was certified five times platinum by the Recording Industry Association of America (RIAA) for sales exceeding 2.5 million in the United States. Because it is a double disc album, it has had its discs counted separately for certification purposes by the RIAA. In Europe, the IFPI certified the album three times platinum in 2000 for sales exceeding 3 million copies.