The events of the game take place shortly after the ending of the first game. The devastating zombie invasion, caused by the scientist Dr. Cooger and his resurrection medicine, was finally stopped, and the young hero Cole could marry his sweetheart Sheila. But alas, if only everything could be so simple... A biker gang starts terrorizing the town. Sheila and Cole find a dead body in Cole's apartment. And soon they discover that not all the traces of the resurrection medicine were destroyed.