Ghostwire: Tokyo is a 2022 action-adventure game developed by Tango Gameworks and published by Bethesda Softworks. The game released worldwide on March 25, 2022 as a one-year timed exclusive for PlayStation 5 and Windows.

Ghostwire: Tokyo is an action-adventure game played from a first-person perspective. The player can use various psychic and paranormal abilities to defeat the ghosts and spirits haunting Tokyo. Combat director Shinichiro Hara described the combat as "karate meets magic", as the player character utilizes hand movements inspired by Kuji-kiri hand gestures to cast spells. When an enemy loses most of their health, its core is exposed and the player can use takedown moves to destroy it. By defeating these spirits and collecting Yokai, the character will collect spirit points and resources used to upgrade their abilities.

The game begins with a spirit (Kazuhiko Inoue) flying over the scene of a traffic collision. The spirit is looking for a body to possess and decides on a boy named Akito (Kensuke Nishi) who was rendered unconscious from the accident. Akito wakes up, still in control of his body except for his right hand, which is under control of the spirit. Soon after, a terrifying fog rolls in, turning anyone caught in it into a spirit, but Akito is spared thanks to the spirit possessing him. A man in a Hannya mask (known only as Hannya (Shunsuke Sakuya)) appears on the digital signs near the area and uses a spell to summon evil entities, sealing the disembodied spirits of the civilians away in cages all across Shibuya. Akito is told by the spirit he needs to hunt Hannya down to stop him, but Akito convinces the spirit to let him go check on his sister, Mari (Asami Seto), who is in a coma at the local hospital.

The spirit grants Akito spirit-based powers to help him fight his way to Mari's room, but find that Hannya has beat them there and wants to use Mari for some sort of ritual. When Akito tries to interfere, Hannya stabs him through the chest and kidnaps Mari. As he lays dying, Akito has a flashback, showing that Mari is comatose due to a house fire. Akito talks to the spirit (who tells Akito to call him KK) and agrees to help him stop Hannya. KK saves Akito's life and tells him to go to a safe house KK had set up before he died.