The Callisto Protocol is a 2022 survival horror action video game developed by Striking Distance Studios and published by Krafton. It was directed by Glen Schofield, who had previously co-created the Dead Space series. The game's story follows Jacob Lee (Josh Duhamel) who is sent to a prison facility set on the Jovian moon Callisto fighting against infected prisoners with an unknown disease while uncovering dark secrets of the facility. Gameplay has players exploring a series of levels, garnering resources while fighting off infected prisoners.

Development of the game began with the formation of Striking Distance Studios in June 2019. Originally developed as a game set in the PUBG: Battlegrounds universe, it later evolved into an original intellectual property.

The game was released for PlayStation 4, PlayStation 5, Windows, Xbox One, and Xbox Series X/S on December 2, 2022. It received mixed reviews. The game reportedly failed to meet the sales expectations of Krafton.

In The Callisto Protocol, players assume the role of Jacob Lee from a third-person perspective. Jacob's health is indicated by an implant on the back of his neck called a "C.O.R.E. Device". Health can be replenished with injectable packs found throughout levels. Jacob can use weapons to combat enemies, as well as a melee system to dodge enemy attacks while looking for openings to strike and kill them. Both combat styles can be mixed up, providing greater variety when facing enemy types. Jacob can collect and review audio logs during gameplay.