With the world a desert wasteland following societal collapse and warfare over resources, a survivor named Max Rockatansky, who is haunted by memories of all the people he has failed to protect, is captured and taken to warlord Immortan Joe's Citadel, where he is imprisoned and used as a "blood bag" for Nux, a sick War Boy. Meanwhile, Imperator Furiosa, one of Joe's lieutenants, is sent in the armoured "War Rig" to trade produce for petrol and ammunition with two of Joe's allies. When Joe realises his five wives are fleeing in the Rig, he leads his army in pursuit of Furiosa, calling on the aid of Gas Town and the Bullet Farm. Nux joins the pursuit with Max strapped to his car, and a battle ensues. Furiosa drives into a sand storm and loses all of her pursuers, except Nux, who attempts to sacrifice himself to blow up the Rig. Max frees himself and restrains Nux, and Furiosa destroys their car.

After the storm, Max finds Furiosa repairing the Rig, accompanied by Joe's wives: Toast, Capable, the Dag, Cheedo, and Angharad, the last of whom is heavily pregnant with Joe's child. Max tries to steal the Rig, but he does not know the code to bypass the kill switches, so he begrudgingly joins up with Furiosa and the wives. Nux boards the Rig as it leaves and attempts to kill Furiosa. He is overcome and thrown out, and Joe's army picks him up when they pass by. Furiosa drives through a canyon controlled by a biker gang, having arranged to trade fuel for her safe passage, but the gang turns on her when they spot an army approaching, forcing her to flee. The bikers detonate the canyon walls to block Joe and then pursue the Rig, only stopping when the fuel pod explodes. Joe drives over the blockade in a monster truck and catches up with the Rig, allowing Nux to board and attack Furiosa again, but he trips before reaching the cab. While helping Max, Angharad falls off the Rig and is fatally run over by Joe, who temporarily halts his pursuit.