"Mustang Sally" is a rhythm and blues (R&B) song written and first recorded by Mack Rice in 1965. It was released on the Blue Rock label (4014) in May 1965 with "Sir Mack Rice" as the artist. The song uses an AAB layout with a 24-bar structure.

It gained greater popularity when Wilson Pickett covered it the following year on a single, a version that was also released on the 1966 album The Wicked Pickett. Also in 1966, John Lee Hooker recorded an entirely different song with a similar title — "Mustang Sally & GTO."